Preterm premature rupture of membranes (PPROM) is a complication of pregnancy responsible for significant perinatal mortality and morbidity. This seminar will focus on different studies addressing obstetric determinants of the health of babies born preterm following PPROM. They were carried out as part of my PhD thesis using data from the EPIPAGE 2 cohort, a population-based cohort of preterm infants born in France in 2011, with different statistical approaches, including propensity-score analysis. This work provides informations that can contribute to improve the quality of antenatal care in order to optimize the outcome of children and families facing prematurity.
Elsa Lorthe was born in 1985 in France. She worked as a midwife and coordinator of clinical and epidemiological studies from 2008 to 2014, and obtained a Master’s degree in Public Health and Epidemiology in 2014. In 2017, she completed a PhD in Perinatal Epidemiology with the theme “Preterm premature rupture of membranes prior 33 weeks’ gestation: antenatal management and determinants of the child’s prognosis”, under the supervision of Prof Gilles Kayem (INSERM U1153, Team EPOPé and Pierre and Marie Curie University, Paris, France). She is currently a post-doctoral researcher at ISPUP.
She has a special interest in preterm birth, preterm premature rupture of membranes and in the evaluation of antenatal care and obstetric practices.
She is member of the I-SPY collaboration (International Spontaneous Preterm birth Young Investigators group) and is involved in updating the French national guidelines about PPROM along with the National College of French Obstetricians and Gynecologists. She is the co-scientific director of the TOCOPROM trial, a double-blinded randomized controlled trial that will assess whether short-term tocolysis reduces perinatal morti-morbidity in cases of PPROM before 34 weeks’ gestation (PI: Prof Gilles Kayem, Trousseau Hospital, Paris, France).