01.04.2015 - 30.04.2019

LIFEPATH - Lifecourse biological pathways underlying social differences in healthy ageing

PHC-01-2014 - 633666

Financing Instituitions
European Commission - Horizon 2020 (2014-2020)

Participating Institutions
Imperial College of Science Technology and Medicine - Coordinator, United Kingdom • University College London, United Kingdom • Hospices Cantonaux Chuv, Switzerland • Universite Paul Sabatier Toulouse III, France • Erasmus Universitair Medisch Centrum Rotterdam, Netherlands • London School of Economics and Political Science, United Kingdom • Trustees of Columbia University in the City of New York, United States • Tyoeterveyslaitos, Finland • Human Genetics Foundation, Italy • Institut National de La Sante et de La Recherche Medicale (INSERM), France • Instituto de Saúde Pública da Universidade do Porto, Portugal • Anti Cancer Council of Victoria, Australia • The Provost, Fellows, Foundation Scholars & The other Members of Board of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin, Ireland • Universita Degli Studi Di Torino, Italy • Zadig Srl, Italy



In developed countries people of different socioeconomic groups experience dramatic differences in healthy ageing, quality of life and life expectancy. The LIFEPATH project will focus on the idea of healthy ageing for all and will work to provide relevant and innovative evidence to underpin future policies and strategies for the promotion of healthy ageing, targeted disease prevention and clinical interventions that address the issue of social disparities in ageing and the social determinants of health.


The project team hope to show that healthy ageing is an achievable goal for society, as it is already experienced by individuals of high socio-economic status. They also aim to improve the understanding of the mechanisms through which healthy ageing pathways diverge by socio-economic status, examine the consequences of the current economic recession on health and the biology of ageing and the consequences of this for social inequalities in health.


LIFEPATH will use an innovative study design that will bring together three areas of research that have been developed separately for a long time: population-based health sciences; omics-biomarker technologies; and social sciences. The project will make use of existing population studies across Europe including the Growing Up in Ireland (GUI) and TILDA studies. They will integrate longitudinal social science research with biology such as molecular epidemiology, which looks at how genetic and environmental risk factors, identified at the molecular level, may contribute to the cause, distribution and prevention of disease across populations.


Weekly Publication

Newborn weight change and childhood cardio-metabolic traits – a prospective cohort study.
BMC Pediatr
Read More