16.07.2018 - 15.07.2021

STEPACHE - The pediatric roots of amplified pain: from contextual influences to risk stratification (POCI-01-0145-FEDER-029087)


Financing Instituitions

Participating Institutions



Chronic pain poses a major burden for individuals and societies. Important challenges persist, regarding the understanding and prediction of amplified pain syndromes that track from childhood. We will use data collected as part of the large Generation XXI cohort, comprising children recruited at birth and evaluated again at ages 4, 7 and 10. Specifically, we will:

1) characterize an amplified pain response phenotype in early adolescence, by using quantitative sensory testing;

2) test the hypothesis of early psychosocial adversity as determinant of the pain experience, via systemic inflammation;

and 3) develop a risk stratification tool for amplified pain to be used in clinical settings based on history of reported pain features. The present project is crucial to typify pain response in children and to stratify the risk of amplified pain. It will also allow to test a novel hypotheses involving the role of psychosocial adversity and inflammation in producing amplified pain.


Weekly Publication

A Comparative Analysis of the Status Anxiety Hypothesis of Socio-economic Inequalities in Health Based on 18,349 individuals in Four Countries and Five Cohort Studies
Scientific Reports
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