Pos-Doc Researcher Position (POCI-01-0145-FEDER-029651)

 

Project: NanoLegaTox. When old meets new: A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures (POCI-01-0145-FEDER-029651)

 

Call start and finish dates: 27th October to 12th November, 2018


 

POST-DOC RESEARCHER POSITION - NanoLegaTox - POCI-01-0145-FEDER-029651

 

Project: NanoLegaTox. When old meets new: A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures (POCI-01-0145-FEDER-029651)

Period for applications: 27th October to 12th November 2018

 

Summary

The Institute of Public Health of the University of Porto (ISPUP) opens a call to hire one PhD Researcher under Sistema de Apoio à Investigação Científica e Tecnológica (SAICT) – Call nr 02/SAICT/2017 - Projeto de Investigação Científica e Desenvolvimento Tecnológico (IC&DT), funded by Programa Operacional Competitividade e Internacionalização through Fundos Europeus de Desenvolvimento Regional (FEDER/FNR) and through national funds (FCT/OE) (POCI-01-0145-FEDER-029087), under the scope of project NanoLegaTox. When old meets new: A novelty study on the human uptake, genotoxicity and immunotoxicity of nanoparticles and legacy contaminants mixtures (POCI-01-0145-FEDER-029651), coordinated by Ana Teresa Reis.

Nanotoxicity assessments usually focus on single nanoparticle (NP) effects, overlooking interactions with other contaminants. In the environment, NPs are expected to co-exist with other toxic species, such as metal(oids), affecting their behavior, uptake and toxicity. The aim of NanoLegaTox is to explore the toxicological effects on human lungs, brain and liver of TiO2 and CeO NPs, when in presence of arsenic and mercury, two extremely toxic chemicals. In vitro studies will be performed on human cell lines (A549; SH-SY5Y; HepG2). Relevant endpoints of cell viability, genotoxicity, oxidative stress, epigeneticity and immunogenicity will be analysed using state-of-the-art techniques. Detailed characterization of NPs in all stages of the study (previous, during, after exposure) will be run. Other goals include i) Understand the contaminants-cell/organ interaction and induced toxicity; ii) Assess the changes in nanoparticles’ physicochemical characteristics upon exposure to other chemical contaminants and determine how this affects their toxicity and interaction with the cell; iii) Establish in vitro and in vivo acute and chronic toxicity of multi-contaminant solutions to lungs, brain and liver, at environmental realistic concentrations; iv) Compare the uptake of the contaminants when alone versus co-exposure on different cells/organs. The strength of the project lies on its novelty, recognized need and multidisciplinarity.

 

  1. Scientific Area: Environmental Health

 

  1. Admission requirements

 

The candidate must have:

  1. PhD in Biology, Toxicology or a close related discipline;
  2. Research experience in the field of environmental health and safety of engineered nanomaterials and toxicology/biology;
  3. Strong skills in cell culture techniques and basic toxicological cellular assays (MTT, LDH, etc.);
  4. Previous experience in in-vitro studies, cyto-genotoxic assays (Comet assay, GSH, ROS or others), and flow cytometry analysis (cell cycle, NPs uptake and others);
  5. Hands-on experience in materials characterization techniques, such as TEM, SEM, IR, Raman, XRD;
  6. First author publications in international peer-reviewed journals related to nanotoxicity;
  7. Excellent English communication skills

 

Since the project involves in-vivo experiments, preference will be given to candidates with experience in laboratory animal science. Demonstration of independent and critical thinking will be highly valued.

 

  1. Activity Outline

 

We are looking for an autonomous researcher who will be responsible for conducting tasks related with in-vitro assessments of human cell lines to NPs and metal(loid)s, using the techniques mentioned in the admission requirements. The researcher will also be responsible for sample preparation and analysis, and data interpretation of in-vivo experiments. The researcher is expected to lead the production of original work publishable in the form of full text papers in international journals and disseminate the project’s results in national and international conferences.

 

  1. Work place and supervision: Portuguese National Institute of Health, under supervision of the project principal investigator Ana Teresa Reis. Address: Rua Alexandre Herculano 321, 4000-055, Porto, Portugal

 

  1. Applicable legislation: The hiring will be governed by the Decree-Law no. 57/2016, of 29 August, as emended by Law no. 57/2017, of July 19, which approves the doctorate hiring regime destined to stimulate scientific and technological employment for all knowledge areas (“RJEC”) and the Labour Code, approved by Law no. 7/2009, of 12th February, in its current wording.

 

  1. Duration: Work contract with non-fixed term according to the Labour Code, with the expected starting date on January 2019. 

 

  1. Salary: The monthly salary is set in accordance with the provisions in RJEC, article 15, no. 1, corresponding to level 33 of the single salary scale approved by Portaria nº 1553-C/2008, de 31 de dezembro at 2,128.34 Euros gross. The salary is paid 14 months per year.

 

 

  1. Selection criteria

 

Selection will be performed according to the Decree-Law no. 57/2016, of 29 August, as emended by Law no. 57/2017, of July 19. After evaluation by the jury, the candidates will be ranked based on their Curriculum Vitae (CV). If the jury considers it necessary, the three best candidates in CV will be called for a face-to-face interview (I). The final classification will be obtained by the following formula: (0.9 x CV) + (0.1 x I), on a scale of 0 to 20 points. If there is no interview, the final classification will be the same as the one obtained in the CV.

 

The target factors for curricular evaluation are those indicated in the admission requirements stated above.

Criteria for Curriculum Vitae evaluation (0 to 20 points):

  1. Research experience in the field of environmental health and safety of engineered nanomaterials and toxicology/biology: 0 to 4 points;
  2. Strong skills in Human cell culture techniques and basic toxicological cellular assays (MTT, LDH, etc.): 0 to 4 points;
  3. Previous experience in in-vitro studies, cyto-genotoxic assays (Comet assay, GSH, ROS or others), and flow cytometry analysis (cell cycle, NPs uptake and others): 0 to 4 points;
  4. Hands-on experience in materials characterization techniques, such as TEM, SEM, IR, Raman, XRD: 0 to 3 points;
  5. First author publications in international peer-reviewed journals related to nanotoxicity: 0 to 2 points;
  6. Experience in laboratory animal science: 0 to 1 points.
  7. Excellent English communication skills: 0 to 2 points.

 

The selection interview evaluation factors, if necessary to be carried out, will be:

a) Professional knowledge and skills to accomplish the work plan: 0 to 9 points;

b) Motivation towards the research project: 0 to 4 points;

c) Professional attitude: 0 to 4 points;

d) Communication skills: 0 to 3 points.

 

If the first candidate withdraws or does not accept the position, the second classified will be called, and so on.

In the event that none of the candidates proves to have the profile indicated for carrying out the work plan, the jury reserves the right not to award the position to the competition.

 

  1. Members of the Jury:

 

Ana Teresa Reis (PI, President)

Carla Costa (Member)

Sónia Fraga (Member)

 

  1. Non-discrimination and equal access policy: ISPUP actively promotes a non-discrimination and equal access policy, wherefore no candidate can be privileged, benefited, impaired or deprived of any rights whatsoever, or be exempt of any duties based on their ancestry, age, sex, sexual preference, marital status, family and economic conditions, instruction, origin or social conditions, genetic heritage, reduced work capacity, disability, chronic illness, nationality, ethnic origin or race, origin territory, language, religion, political or ideological convictions and union membership.

 

  1. Documents Required

Application period will be open from 27th October to 12th November 2018.

The applications must be send by e-mail to secretaria@ispup.up.pt (Cc: ana.reis@insa.min-saude.pt) and must include:

  1. Letter of motivation, in which the candidate must state the reasons to apply for this position and how his/her academic profile and experience fit the project;
  2. Curriculum Vitae, with full name and contact information;
  3. Copy of the certificate(s) of the qualification(s);
  4. Any documents that the candidates deem relevant to assess their merits.

 

The submitted documents should be named with the first and last name of the candidate (eg: LetterMotivation_JohnDoe; CV_JohnDoe, etc.) and should not exceed 5 MB as a whole. Please highlight the following reference in the subject field of the application email: “Postdoc Researcher_NanoLegaTox_candidate first and last name”.

 

  1. Notification of results: 

 

Candidates will be notified by e-mail and all relevant information will be published at the ISPUP website (http://www.ispup.up.pt).

 

Note:

 

Non-discrimination and equal access policy: ISPUP actively promotes a non-discrimination and equal access policy, wherefore no candidate can be privileged, benefited, impaired or deprived of any rights whatsoever, or be exempt of any duties based on their ancestry, age, sex, sexual preference, marital status, family and economic conditions, instruction, origin or social conditions, genetic heritage, reduced work capacity, disability, chronic illness, nationality, ethnic origin or race, origin territory, language, religion, political or ideological convictions and union membership.

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