Generation XXI

Henrique Barros


The Generation XXI cohort has been accompanying 8647 participants born in public maternity hospitals of the Metropolitan Area of Porto since 2005.

It was created with the aim of characterising prenatal and postnatal development and identifying its determinants, in order to better understand the state of health in childhood, adolescence and adulthood. 

Starting from an initial assessment at birth, the participants were then assessed at 6, 15 and 24 months, and at 4, 7, 10 and 13 years of age.

Throughout the years of follow-up, tests such as anthropometry, blood pressure measurement, blood sampling and bioimpedance were carried out. In addition, more specific exams such as electrocardiograms, spirometry, evaluation of puberty and cognitive assessments have also been part of the range of parameters evaluated.

Generation XXI serves as the basis for a vast body of scientific research in areas such as perinatal and pediatric health, obesity and metabolic health, lifestyles, cardiovascular health, musculoskeletal health, among others.

In addition to producing scientific evidence on the mechanisms that give rise to disease, Generation XXI plays an important role in planning health intervention strategies


Maia I , Severo M , Lopes C , Santos AC

Public Health Nutr, 2022 May 23;1-21. doi: 10.1017/S1368980022001239. Online ahead of print.

van Meel ER, Mensink-Bout SM, den Dekker HT, Ahluwalia TS, Annesi-Maesano I, Arshad SH, Baïz N , Barros H , von Berg A, Bisgaard H, Bønnelykke K, Carlsson CJ, Casas M, Chatzi L, Chevrier C, Dalmeijer G, Dezateux C, Duchen K, Eggesbø M, van der Ent C, Fantini M, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, Granell R, Griffiths LJ, Inskip H, Jerzynska J, Karvonen AM, Keil T, Kelleher C, Kogevinas M, Koppen G, Kuehni CE, Lambrechts N, Lau S, Lehmann I, Ludvigsson J, Magnus MC, Mélen E, Mehegan J, Mommers M, Andersen AN, Nystad W, Pedersen ESL, Pekkanen J, Peltola V, Pike KC, de Moira AP, Pizzi C, Polanska K, Popovic M, Porta D, Roberts G, Santos AC, Schultz ES, Standl M, Sunyer J, Thijs C, Toivonen L, Uphoff E, Usemann J, Vafeidi M, Wright J, de Jongste JC, Jaddoe VWV, Duijts L

Eur Respir J, 2022 Apr 29;2102395. doi: 10.1183/13993003.02395-2021. Online ahead of print.

Main Results


Cátia Ferreira
Research Support - Generation XXI