16.07.2018 - 15.04.2022

STEPACHE - The pediatric roots of amplified pain: from contextual influences to risk stratification

PTDC/SAU-EPI/29087/2017 (POCI-01-0145-FEDER-029087)

Financing Instituitions

Participating Institutions



Principal Investigator: Raquel Lucas


Financiamento aprovado pelo Programa Operacional Competitividade e Internacionalização na sua componente FEDER, pela Fundação para a Ciência e Tecnologia, I.P.

ProponentInstituto de Saúde Pública da Universidade do Porto

Financial Support:
Program: P2020|COMPETE - Projetos em Todos os Domínios Científicos
Financial Institution: FCT - Fundação para a Ciência e Tecnologia
Financial Geographic Scope: Nacional
Financing Agreement Date: 2018-05-14

Approval date: 2018-04-24
Start Date: 2018-07-16
Estimated date of completion: 2022-04-15


Total Budget: 238.183,30 €



Chronic pain poses a major burden for individuals and societies. Important challenges persist, regarding the understanding and prediction of amplified pain syndromes that track from childhood. We will use data collected as part of the large Generation XXI cohort, comprising children recruited at birth and evaluated again at ages 4, 7 and 10. Specifically, we will:

1) characterize an amplified pain response phenotype in early adolescence, by using quantitative sensory testing;

2) test the hypothesis of early psychosocial adversity as determinant of the pain experience, via systemic inflammation;

and 3) develop a risk stratification tool for amplified pain to be used in clinical settings based on history of reported pain features. The present project is crucial to typify pain response in children and to stratify the risk of amplified pain. It will also allow to test a novel hypotheses involving the role of psychosocial adversity and inflammation in producing amplified pain.



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