16.07.2018 - 15.07.2021

STEPACHE - Raízes pediátricas da resposta ampliada à dor: das influências contextuais à estratificação do risco (POCI-01-0145-FEDER-029087)


Financing Instituitions

Participating Institutions



Data de início: 16 de julho 2018

Data de fim: 15 de julho 2021


Orçamento total: 238 193,30€

Orçamento atribuído ao ISPUP: 238 193,30€


Investigador Responsável: Raquel Lucas


Chronic pain poses a major burden for individuals and societies. Important challenges persist, regarding the understanding and prediction of amplified pain syndromes that track from childhood. We will use data collected as part of the large Generation XXI cohort, comprising children recruited at birth and evaluated again at ages 4, 7 and 10. Specifically, we will:

1) characterize an amplified pain response phenotype in early adolescence, by using quantitative sensory testing;

2) test the hypothesis of early psychosocial adversity as determinant of the pain experience, via systemic inflammation;

and 3) develop a risk stratification tool for amplified pain to be used in clinical settings based on history of reported pain features. The present project is crucial to typify pain response in children and to stratify the risk of amplified pain. It will also allow to test a novel hypotheses involving the role of psychosocial adversity and inflammation in producing amplified pain.


Publicação Semanal em destaque

Pregnancy and Breastfeeding During COVID-19 Pandemic: A Systematic Review of Published Pregnancy Cases.
Front Public Health
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