ISPUP

Sónia Fraga licenciou-se em Biologia pela Faculdade de Ciências da Universidade do Porto (FCUP) em 1998 e obteve o grau de Doutor em Biologia Humana pela Faculdade de Medicina da Universidade do Porto (FMUP) em 2006.
Atualmente, ela é Investigadora Auxiliar do Departamento de Saúde Ambiental do Instituto Nacional de Saúde Doutor Ricardo Jorge e líder do grupo Nanomateriais – Segurança e Saúde do Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR). Os seus principais interesses de investigação são a segurança e efeitos na saúde dos nanomateriais. Neste domínio, já participou em vários projetos I&D nacionais e Internascionais, nomeadamente nos projetos ERA-NET SIINN NanoToxClass e CERASAFE, e é Investigadora Principal do projeto NanoBioBarriers – Estudo dos mecanismos subjacentes aos efeitos das nanopartículas metálicas nas barreiras biológicas – contribuição para a implementação do conceito safe-by-design (PTDC/MED-TOX/31162/2017).
Sónia Fraga é também Professora Auxiliar Convidada da FMUP, membro da Sociedade Portuguesa de Farmacologia e da Comissão Técnica em Nanotecnologias (CT-194).

Projetos de investigação nacionais

Ano

Título

Artigos

2022

Correia AS , Fraga S , Teixeira JP , Vale N

Cell Model of Depression: Reduction of Cell Stress with Mirtazapine

, 2022 Apr 29;23(9):4942. doi: 10.3390/ijms23094942.

2022

Bessa MJ , Brandão F , Fokkens PHB, Leseman DLAC, Boere AJF, Cassee FR, Salmatonidis A, Viana M, Monfort E , Fraga S , Teixeira JP

Unveiling the Toxicity of Fine and Nano-Sized Airborne Particles Generated from Industrial Thermal Spraying Processes in Human Alveolar Epithelial Cells

Int J Mol Sci, 2022 Apr 13;23(8):4278. doi: 10.3390/ijms23084278.

2021

Bessa MJ , Brandão F , Fokkens PHB, Leseman DLAC, Boere AJF, Cassee FR, Salmatonidis A, Viana M, Vulpoi A, Simon S, Monfort E , Teixeira JP , Fraga S

In Vitro Toxicity of Industrially Relevant Engineered Nanoparticles in Human Alveolar Epithelial Cells: Air-Liquid Interface versus Submerged Cultures

Nanomaterials (Basel), 2021 Nov 27;11(12):3225. doi: 10.3390/nano11123225.

2021

Moreira L , Costa C , Pires J , Teixeira JP , Fraga S

How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets

Mutat Res Rev Mutat Res, Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12.

2021

Neves CS, Sousa I, Freitas MA, Moreira L, , Costa C , Teixeira JP , Fraga S , Pinto E, Almeida A, Scharnagl N, Zheludkevich ML, Ferreira MGS, Tedim J

Insights into corrosion behaviour of uncoated Mg alloys for biomedical applications in different aqueous media

Journal of Materials Research and Technology, 2021,13:1908-1922; DOI: https://doi.org/10.1016/j.jmrt.2021.05.090

2021

Viana M, Salmatonidis A, Bezantakos S, Ribalta C, Moreno N, Córdoba P, Cassee FR, Boere J , Fraga S , Teixeira JP , Bessa MJ , Monfort E

Characterizing the Chemical Profile of Incidental Ultrafine Particles for Toxicity Assessment Using an Aerosol Concentrator.

Ann Work Expo Health, 2021 Jul 27;wxab011. doi: 10.1093/annweh/wxab011. Online ahead of print.

2021

Brandão F , Costa C , Bessa MJ , Dumortier E, Debacq-Chainiaux F, Hubaux R, Salmon M, Laloy J, Stan MS, Hermenean A, Gharbia S, Dinischiotu A, Bannuscher A, Hellack B, Haase A , Fraga S , Teixeira JP

Genotoxicity and Gene Expression in the Rat Lung Tissue following Instillation and Inhalation of Different Variants of Amorphous Silica Nanomaterials (aSiO 2 NM).

Nanomaterials (Basel), 2021 Jun 7;11(6):1502. doi: 10.3390/nano11061502.

2021

Bessa MJ , Brandão F , Fokkens P, Cassee FR, Salmatonidis A, Viana M, Vulpoi A, Simon S, Monfort E , Teixeira JP , Fraga S

Toxicity assessment of industrial engineered and airborne process-generated nanoparticles in a 3D human airway epithelial in vitro model.

Nanotoxicology, 2021 Mar 18;1-16. doi: 10.1080/17435390.2021.1897698. Online ahead of print.

2020

Brandão F , Fernández-Bertólez N, Rosário F , Bessa MJ , Fraga S , Pásaro E , Teixeira JP , Laffon B , Valdiglesias V , Costa C

Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HEPG2, A172 and SH-SY5Y).

Nanomaterials (Basel), 2020 Feb 27;10(3). pii: E412. doi: 10.3390/nano10030412.

2020

Bessa MJ , Brandão F , Viana M, Gomes JF, Monfort E, Cassee FR , Fraga S , Teixeira JP

Nanoparticle exposure and hazard in the ceramic industry: an overview of potential sources, toxicity and health effects.

Environ Res, 2020 May;184:109297. doi: 10.1016/j.envres.2020.109297. Epub 2020 Feb 24.

2019

Bessa MJ , Brandão F , Querido M , Costa C , Pereira CC , Valdiglesias V , Laffon B , Carriere M , Teixeira JP , Fraga S

Optimization of the harvesting and freezing conditions of human cell lines for DNA damage analysis by the alkaline comet assay.

Mutat Res, 2019 Sep;845:402994. doi: 10.1016/j.mrgentox.2018.12.002. Epub 2018 Dec 10.

2019

Dorier M, Tisseyre C, Dussert F, Béal D, Arnal ME, Douki T, Valdiglesias V, Laffon B , Fraga S , Brandão F , Herlin-Boime N, Barreau F, Rabilloud T, Carriere M

Toxicological impact of acute exposure to E171 food additive and TiO2 nanoparticles on a co-culture of Caco-2 and HT29-MTX intestinal cells.

Mutat Res, 2019 Sep;845:402980. doi: 10.1016/j.mrgentox.2018.11.004. Epub 2018 Nov 22.

2019

Pereira I , Fraga S , Silva S , Teixeira JP , Gama M

In vitro genotoxicity assessment of an oxidized dextrin-based hydrogel for biomedical applications.

J Appl Toxicol, 2019 Apr;39(4):639-649. doi: 10.1002/jat.3754. Epub 2018 Nov 28.

2019

Pereira I , Fraga S , Maltez L, Requicha J, Guardão L, Oliveira J, Prada J, Alves H, Santos JD , Teixeira JP , Oliveira MBPP

In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and its effectiveness as a carrier and stabilizer of granular synthetic bone substitutes.

J Biomed Mater Res A, 2019 Mar 28. doi: 10.1002/jbm.a.36683. [Epub ahead of print]

2018

Leal J, Teixeira-Santos L, Pinho D, Afonso J, Carvalho J, de Lourdes Bastos M, Albino-Teixeira A , Fraga S , Sousa T

l-proline supplementation improves nitric oxide bioavailability and counteracts the blood pressure rise induced by angiotensin II in rats.

Nitric Oxide, 2018 Nov 10. pii: S1089-8603(17)30202-1. doi: 10.1016/j.niox.2018.10.007. [Epub ahead of print]

2017

Mendes A , Costa C , Pereira CC , Fraga S , Barbosa F Jr , Teixeira JP

Recent developments on Occupational and Environmental Toxicology.

J Toxicol Environ Health A, 2017 Oct 2:1. doi: 10.1080/15287394.2017.1382124. [Epub ahead of print]

2017

Esteves FC , Teixeira E , Amorim T , Costa C , Pereira CC , Fraga S , De Andrade VM , Teixeira JP

Assessment of DNA damage in a group of professional dancers during a 10-month dancing season.

J Toxicol Environ Health A, 2017 Jul 11:1-8. doi: 10.1080/15287394.2017.1331599. [Epub ahead of print]

2017

Mesquita B , Lopes I , Silva S , Bessa MJ , Starykevich M, Carneiro J, Galvão TLP, Ferreira MGS, Tedim J , Teixeira JP , Fraga S

Gold nanorods induce early embryonic developmental delay and lethality in zebrafish (Danio rerio).

J Toxicol Environ Health A, 2017 Jul 11:1-16. doi: 10.1080/15287394.2017.1331597. [Epub ahead of print]

2017

Bessa MJ , Carla Costa , Reinosa J , Pereira CC , Fraga S , Fernández J , Bañares MA , Teixeira JP

Moving into advanced nanomaterials. Toxicity of rutile TiO2 nanoparticles immobilized in nanokaolin nanocomposites on HepG2 cell line.

Toxicol Appl Pharmacol, 2017 Feb 1;316:114-122. doi: 10.1016/j.taap.2016.12.018. Epub 2016 Dec 28.

2016

Valdiglesias V , Fernández-Bertólez N , Kiliç G , Costa C , Fraga S , Bessa MJ , Pásaro E , Teixeira JP , Laffon B

Are iron oxide nanoparticles safe? Current knowledge and future perspectives.

J Trace Elem Med Biol, 2016 Dec;38:53-63. doi: 10.1016/j.jtemb.2016.03.017. Epub 2016 Mar 31.

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Sónia Fraga

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