LIFEPATH - Lifecourse biological pathways underlying social differences in healthy ageing

Sílvia Fraga

Principal Investigator

Integrated Member (PhD)

Type of project:



PHC-01-2014 - 633666

Proposing institution:

Imperial College of Science Technology and Medicine, United Kingdom

Participating institutions:

University College London, United Kingdom • Hospices Cantonaux Chuv, Switzerland • Universite Paul Sabatier Toulouse III, France • Erasmus Universitair Medisch Centrum Rotterdam, Netherlands • London School of Economics and Political Science, United Kingdom • Trustees of Columbia University in the City of New York, United States • Tyoeterveyslaitos, Finland • Human Genetics Foundation, Italy • Institut National de La Sante et de La Recherche Medicale (INSERM), France • Instituto de Saúde Pública da Universidade do Porto, Portugal • Anti Cancer Council of Victoria, Australia • The Provost, Fellows, Foundation Scholars & The other Members of Board of the College of the Holy & Undivided Trinity of Queen Elizabeth Near Dublin, Ireland • Universita Degli Studi Di Torino, Italy • Zadig Srl, Italy

Sources of financing:

European Commission - Horizon 2020 (2014-2020)

Start date:


(Predicted) End date:


Research line:

L2 - Syndemics, health inequalities and vulnerable populations

Research lab:

Social Adversity and Health Inequalities



In developed countries people of different socioeconomic groups experience dramatic differences in healthy ageing, quality of life and life expectancy. The LIFEPATH project focus on the idea of healthy ageing for all and will work to provide relevant and innovative evidence to underpin future policies and strategies for the promotion of healthy ageing, targeted disease prevention and clinical interventions that address the issue of social disparities in ageing and the social determinants of health.

The project team hope to show that healthy ageing is an achievable goal for society, as it is already experienced by individuals of high socio-economic status. They also aim to improve the understanding of the mechanisms through which healthy ageing pathways diverge by socio-economic status and to examine the consequences of the current economic recession on health and biology of ageing.

LIFEPATH will use an innovative study design that will bring together three areas of research that have been developed separately for a long time: population-based health sciences; omics-biomarker technologies; and social sciences. The project will make use of existing population studies across Europe as for instance the Portuguese Cohorts – EPIPorto, EPITeen and Geração XXI.

The LIFEPATH project is a collaboration of leading institutions in Europe, USA and Australia. It brings together experts in the field of study who are committed to the successful completion of the project.

Research team