MOZA-BC

Nuno Lunet

Coordinator:

MOZA-BC, an acronym that stands for Mozambican Breast Cancer, is the first longitudinal study of breast cancer patients in the country of Mozambique.

It was set up in 2015 by Mozambique’s three main central hospitals (Maputo, Beira and Nampula) in collaboration with ISPUP, in order to help address the lack of information on the distribution of breast cancer subtypes, available treatments, and disease survival figures in the country.

262 Mozambican women, diagnosed with breast cancer between 2015 and 2017, have since been followed by the study team. 

Some of the already published results show, for example, that almost a quarter of the women have triple negative breast cancer (the most aggressive and lethal), many are diagnosed at an advanced stage of the disease and, three years after diagnosis, half of the patients have already died.

As part of the cohort, a multidisciplinary breast cancer group consultation was set up for the first time in Mozambique, which has since shown to have a very beneficial impact on the survival of these women. 

Information was also collected on breast cancer and HIV infection in Mozambican women. This data, combined with other African and North American studies, showed that women with HIV are diagnosed with breast cancer at a more advanced stage of the disease and that their chance of survival is lower than that of women without HIV who are also diagnosed with the disease.

With MOZA-BC, it has been possible to investigate the role of different risk factors in the development of each subtype of breast cancer in African women.

The data collected has helped to answer important scientific questions and led to the publication of scientific articles in international journals. 

Publications

2021
Brandão M , Guisseve A , Damasceno, A , Bata G, Silva-Matos C, Alberto M, FerroJ, Garcia C, Zaqueu C, Lorenzoni C, Leitão D, Soares O, Gudo-Morais A, Schmitt F , Morais S , Tulsidas, S , Carrilho C , Lunet, N

Cancer Epidemiol Biomarkers Prev, 2021 Apr 13;cebp.1730.2020

2020
Brandão, M , Guisseve A, Bata G , Machado, JF , Alberto M, Ferro J, Garcia C, Zaqueu C, Jamisse A, Lorenzoni C, Piccart-Gebhart M, Leitão D, Come J, Soares O, Gudo-Morais A, Schmitt F , Tulsidas, S , Carilho C , Lunet, N

Oncologist, 2020 Dec 16. doi: 10.1002/onco.13643. Online ahead of print.

Main Results