MIND-Matosinhos: Multiple Interventions to Prevent Cognitive Decline

Vítor Tedim Cruz

Principal Investigator

Integrated Member (PhD)

Type of project:




Participating institutions:

Instituto de Saúde Pública da Universidade do Porto, Câmara Municipal de Matosinhos, Unidade Local de Saúde de Matosinhos (ULSM), Faculdade de Medicina da Universidade do Porto, Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto, Faculdade de Desporto da Universidade do Porto, Neuroinova Lda.

Sources of financing:

Portugal Inovação Social, Programa Operacional Inclusão Social e Emprego, Portugal 2020 e União Europeia através do Fundo Social Europeu

Start date:


(Predicted) End date:


Total budget:


Research line:

L4 - Patient and Population Outcomes Research

Research lab:

Cognitive Impairment in Diseases Involving the Nervous System


MIND-Matosinhos: Multiple Interventions to Prevent Cognitive Decline – 

Implementation of non-pharmacological interventions to prevent cognitive decline in the Matosinhos municipality

Dementia is a disease that limits an individual’s quality of life and autonomy, and also has a high family, economic and social impact. However, until now, there are no drugs to stabilize cognitive performance in individuals with mild cognitive impairment, preventing its progression to dementia.

Therefore, based on the MIND study implemented in ACES-Porto Ocidental, in 2019, this project aims to assess the impact of a community-based cognitive decline prevention program, composed of multiple non-pharmacological strategies, entitled “MIND-Matosinhos: Multiple Interventions to Prevent Cognitive Decline”.

This study will include citizens living in Matosinhos and/or who are enrolled in a Primary Healthcare Unit of the ULSM, and who meet the following criteria: 1) score ≤2 standard deviations (SD) below the mean for age and education in the Montreal Cognitive Assessment (MoCA); 2) score ≥6 on the Cardiovascular Risk Factors, Aging and Dementia Dementia Risk Score; 3) age between 18 and 85 years; 4) education of at least 4 years; 5) autonomy to perform daily living activities; 6) absence of contraindications for the practice of physical exercise; 7) absence of a previous diagnosis of dementia or severe disability.

Potential participants will be referenced by several services of the Pedro Hispano Hospital, by the Primary Healthcare Units of the ULMS, by other institutions and associations of the Matosinhos municipality, and also through the active search of individuals with greater socio-economic deprivation or an individual’s self-proposal.

The intervention program will be implemented for a minimum duration of three months, up to 12 months, and will include the following strategies:

1) cognitive training;

2) physical exercise;

3) nutrition education;

4) adaptation to memory loss;

5) assessment and correction of hearing impairment.

Approximately 300 individuals at-risk for developing dementia will be included, of which 150 will be submitted to an intensive intervention and 150 will receive a less intensive intervention. The caregivers and/or partners of the study’s participants will also be included, and will participate in activities related to nutrition education and adaptation to memory loss.

Contact information

E-mail: mind.matosinhos@ispup.up.pt

Telephone: 912 371 271

Research Team